This sub-series contains annual reports and periodical volumes published by the Isthmian Canal Commission, an organization appointed by the United States Government to oversee the development and construction of a canal in Central America. Material includes studies on the feasibility and logistics of canal construction and reports on Panama Canal progress. Maps produced by the commission and a letter from a former employee are also included in this sub-series.

Unboxed material is shelved at the end of the collection.